Adverse health effects from exposure to mercury (Hg) exposure from dental amalgam fillings cannot be ruled out in a small and more susceptible part of the exposed population. Individual differences in toxicokinetics may explain susceptibility to mercury. F2 mice showed a large inter-individual variation in Hg accumulation, showing that multiple genetic factors influence the Hg toxicokinetics in the mouse.
Apolipoprotein-E genotyping has been investigated as an indicator of susceptibility to heavy metal neurotoxicity. Moreover, apo-E4 is a major risk factor for neurodegenerative conditions, including Alzheimer's disease (AD). A theoretical biochemical basis for this risk factor is discussed. Apo-E genotyping warrants investigation as a clinically useful biomarker for those at increased risk of neuropathology, including AD, when subjected to long-term mercury exposures.
Mercuryexposure.info was created and is maintained by consumers injured from exposure to mercury vapor and particles released by their dental amalgam fillings during placement, polishing, removal and day to day use. We are dedicated to providing accurate, up to date information on the many facets of dental mercury amalgam fillings.