Study Scandals

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Dental Amalgam Scandals A known neurotoxin such as mercury, with a vast history of scientific studies indicating harm at low levels of exposure, could not remain on the market as a medical implant for over 30+ years without a plethora of scandals to accompany it. Many of the articles in this section are based on researchers first hand experience with various health agencies of the federal government and Freedom of Information (FOIA) documents obtained by consumer advocacy groups.
The American Dental Association (ADA) The history of The American Dental Association (ADA) is inextrictably tied to the promotion of dental amalgam and its alleged safety. The ADA has spent up to 2 million dollars a year lobbying on behalf of its interests. Through its affiliates, the ADA dictates dental school cirriculum in the USA. In addition members of the ADA have lead The National Institute of Dental and Craniofacial Research and The FDA's Centers for Devices and Radiological Health.
The Agency for Toxic Substances and Disease Registry (ATSDR) The Agency for Toxic Substances and Disease Registry continually fails in its mission to serve the public through responsive public health actions to protect people from environmental hazards and toxic exposures. ATSDR has yet to educate communities, partners, and policy makers about the health risks associated with dental mercury fillings. ATSDR authored the 1999 "toxicological profile on mercury".
The Environmental Protection Agency (EPA) The mission of the EPA is to protect human health and to safeguard the natural environment — air, water, and land — upon which life depends. The EPA's mercury amalgam waste regulations have been overtly influenced by the American Dental Association. At 24 tons, dentists are some of the largest contributors of mercury into our environment. In addition the EPA fails to address direct to air releases from dental offices and dental mercury emissions from crematories.
The European Union - EU - SCENIHR The European Union's Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) provides opinions on emerging or newly-identified health and environmental risks and on broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other community risk assessment bodies. SCENIHR released a blatantly misleading report, promoting the safety of mercury dental fillings.
The Food and Drug Administration (FDA) For over 34 years the FDA avoided properly classifying dental mercury amalgam fillings (a medical implant). In 2009 the FDA lost a lawsuit and were mandated by a court order to classify amalgam fillings. During the past 33 years the FDA has consistently acted in a manner opposite their mission statement in regards to dental amalgam. "FDA is responsible for protecting the public health by assuring the safety, efficacy and security of... "medical devices".
FDI World Dental Federation FDI World Dental Federation is a membership organisation composed of more than 200 member National Dental Associations and specialist groups, altogether representing more than one million dentists worldwide. The organisation is governed by a Council of delegates from member associations that are elected by a General Assembly during the FDI Annual World Dental Congress (AWDC).
The National Institute of Dental and Craniofacial Research (NIDCR) The mission of the National Institute of Dental and Craniofacial Research (NIDCR) is to improve oral, dental and craniofacial health through research, research training, and the dissemination of health information. NIDCR is the Nation’s leading funder of oral, dental, and craniofacial research. 75% of NIDCR’s budget goes to grantees at universities, dental schools, and medical schools across the country
The National Institutes of Health (NIH) The NIH, a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency. NIH is the largest source of funding for medical research in the world. The NIH killed funding to the researcher who was able to show that mercury reproduced three of the biochemical hallmarks of Alzheimer's Disease.
The Office of Management and Budget (OMB) The OMB reviews agency budgets, management, legislative, regulatory, financial, procurement, and other proposals; assures that all such proposals are consistent with relevant statutes and Presidential objectives; provides both short-range and long-range analysis and advice to government officials on a variety of subjects; and develops Government-wide policies.
The Occupational Safety & Health Administration (OSHA) OSHA's role is to assure safe and healthful working conditions for workers by authorizing enforcement of the standards developed under the Act. But, despite knowledge of mercury's widespread use in dentistry and elevated levels of mercury in dental offices during placement, polishing and removal OSHA refuses to enforce current regulations that would protect both staff and patients from uneccessary mercury exposure.
Study Scandals There have been many studies claiming amalgam safety which have downplayed mercury exposure and adverse health effects from that exposrue. Unfortunately, only those studies showing safety get huge coverage in the press without ever mentioning any of those studys inherent flaws or conflicts of interests. In this section we offer a critical look at those studies.
The United Nations - UN The United Nations Environment Programme (UNEP) coordinates United Nations environmental activities at the global and regional level. Its mandate is to coordinate the development of environmental policy consensus by keeping the global environment under review and bringing emerging issues to the attention of governments and the international community for action.
The World Health Organization - WHO WHO is the directing and coordinating authority for health within the United Nations system. It is responsible for providing leadership on global health matters, shaping the health research agenda, setting norms and standards, articulating evidence-based policy options, providing technical support to countries and monitoring and assessing health trends. The dental division within The WHO has continually released unsanctioned papers promoting the safety of mercury fillings.

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Tuesday, 20 September 2011 08:58

Understanding the inherent flaws and methodology in Rodney Mackert's mercury exposure claims

ada

When reporting on how much mercury is released from dental mercury amalgam fillings most journalists cite The American Dental Association's spokesman Rodney Mackert's "estimates" without understanding any of the inherant flaws in his methodology.  Read on to find out more about the debunking of his dubious claim that only "minute amounts of mercury are released by dental amalgam".

Vas Aposhian (Aposhian, 1992 ) documented the fact, now universally accepted by the scientific community, that dental amalgam fillings contribute the majority of mercury body burden in the general population. These findings have been corroborated by other research including human cadaver studies. 

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Boyd Haley PhD

Boyd Haley PhD quantitatively measured mercury release from dental amalgams ranging from 4 - 22 micrograms/cm2 per day - "without galvanism, excess heat or pressure from chewing - all factors that increase mercury release from amalgams in the mouth". This study was done using very small single-spill fillings in a sealed container.

 

Vimy and Lorscheider derived an average absorbed mercury dose of 10 μg per day from amalgam fillings from their measurements of mouth air. Other groups have reported varying estimates. On the low end, Mackert and Berglund et. al., by applying assumptions and inferences concerning how much mouth air is actually inhaled, arrived at average daily doses for subjects with twelve or more amalgam surfaces, of 1.83 and 1.7 μg, respectively (not zero). The question of inhaling mouth air should be moot, though, because elemental mercury vapor is lipophilic, and is absorbed easily through cell membranes and mucosal barriers. On the high end, Patterson et. al. reported absorbed doses of as much as 27 μg per day. Skare and Engqvist, by metabolic methods, arrived at a figure of 12 μg per day for a group of subjects with an average of 47 amalgam surfaces.

The current best accepted reference on absorbed dose of mercury from amalgam fillings comes from the World Health Organization proceedings of 1991, which was the report of a meeting of toxicologists and environmental health specialists (few dentists and no industry lobbyists, the opposite of the 1997 WHO meeting!). The conclusion of that group was that the average person in the industrial world with an average number of amalgam fillings, and no occupational exposure to mercury would absorb between 3 – 17 μg per day, with an average of 10 μg, from the fillings; 2.3 μg from all dietary sources; and 0.3 μg from all other environmental sources.

Mark Richardson PhD (previously of Health Canada) presented a chart (below) summarizing eighteen separate estimates of mercury exposure due to amalgam in adults. The range of the estimates intersects with limits recommended for non-occupational exposure by  the US Environmental Protection Agency (EPA) and California's Environmental Protection Agency (CalEPA), as shown by the vertical blue and red lines.

Published Estimates of Hg Exposure in Adults With Dental Amalgam (Mercury Fillings)

rodney-mackertThese measurements showed that mercury release from amalgams vastly exceed the ʻestimatedʼ release reported by ADA 'authority' Rodney Mackert, DDS, who claimed that 7 fillings release only a single microgram of mercury per day - according to a Wall Street Journal article. It is important to note that Mackert, rather than directly measuring the actual quantity of mercury released by amalgams, instead "estimated" the amount of mercury released from amalgam fillings by looking at the mercury level in the urine of several test subjects. Mackert has no training in toxicology as he is a practicing dental materials expert. 

It is well established that less than 10% of mercury leaves the body by the kidney/urinary route (the vast majority leaving by the bilary transport/fecal route). As a result of this flawed methodology the ADA estimated level of mercury release by amalgam grossly understates the amount of the mercury released. 

Inorganic mercury (as from dental mercury fillings) is mainly execreted in the FECES !

1931
There are only a few previous studies on fecal levels of mercury after amalgam placement. Borinski, 1931, measured a total excretion (feces + urine) of 10-100 micrograms/day in 50% and more than 100 in 50% of the children after amalgam therapy. The increased levels lased for some months and subsequently dropped considerably. The levels in feces were generally five (5) times higher than those in urine.

1957
Frykholm, 1957, found somewhat increased urine mercury levels after amalgam placement in dogs and in humans but up to 87.000 micrograms/100g feces in dog and 1.900 micrograms/100 g in humans where a much smaller amount of amalgam was used. A second peak of mercury excreation occurred after removal of the fillings, irrespective of precautions (rubber dam) or extraction of teeth instead of drilling.

1960
Minimal studies show that the distribution of the execretion between the different routes is dose dependent, Rothstein & Hayes, 1960

1962
The influence of the size of the dose on the distribution and elimination of inorganic mercury Hg(NO3)2 in the rat, Ceber 1962.

1964
Hg is excreted in both urine and feces. Chronic exposure to Hg0, as from dental amalgam, results in a steady state where daily uptake and total daily excretion (urine + faeces) of Hg are in equilibrium, Rothstein & Hayes, 1964

1978
Cherian et al. 1978 exposed human volunteers to radioactively labelled Hg vapor, 79% of the excreted amount was in feces.

1980
Kristensen & Hansen 1980 i.e. at decreasing doses the importance of fecal route increases, 85% was found in feces.

1987
However, at exposure levels sufficient to produce the same urinary Hg concentrations associated with up to 128 amalgam-filled tooth surfaces (the reported maximum number of filled tooth surfaces in the US population; see Table 1), urinary excretion represents 40% of total daily excretion of Hg. This latter value can be determined from the data presented by Roels et al. (1987), assuming that adult working males inhale an average of 6.6 m3 of air in an 8 hour shift (U.S. EPA, 1989a), and that 80% of inhaled Hg is absorbed. From the data of Roels et al. (1987), the proportion of total Hg excretion which occurred via the urine was 39.8 ± 12.5 %.

1989 - 1990
More recent experiments on sheep, Hahn et al, 1989, and monkeys, Hahn et al 1990, clearly shows the major part of amalgam derived mercury to pass via the gastrointestinal tract where some of it is absorbed in tissues. These animal experiments also demonstrated a considerable absorption directly into the jaw bone an Hg accumulation in various tissues.

1992
Skare, 1992, estimated that half of the gastrointestinal mercury might be swallowed material from corrosion and abrasion and half absorbed and execreted into the gastrointestinal tract. More accurate information is difficult to obtain when amalgam is still present in the teeth. Mercury vapor is generally considered to be the most toxic form of inorganic mercury but also swallowed mercury compounds with low solubility have caused serve poisonings after long exposure.

1992
Skare & Engqvist, 1992, found fecal excretion of mercury from amalgam in the range 27-190 micrograms/day in persons having from 18-82 amalgam surfaces (crowns counted as 6 surfaces). Urine levels were "normal" with only one value over 8 micrograms/day.

1994
In feces of amalgam bearers, Skare and Engqvist 1994

1995
Hg is excreted in both urine and feces. Chronic exposure to Hg0, as from dental amalgam, results in a steady state where daily uptake and total daily excretion (urine + faeces) of Hg are in equilibrium, Weiner and Nylander 1995

1997
In feces of amalgam bearers , Bjorkman et al. 1997

1998
In feces of amalgam bearers, Engqvist et al. 1998


A study done by Dr. David Quig of Doctorʼs Data showed that an average of 60 micrograms are excreted daily in the feces of the average amalgam bearer. Therefore, if only 1 microgram were excreted by the required 7 amalgams, as suggested by Mackert and the ADA, to reach this average fecal excretion rate a person would have to have 420 amalgams.

It is important to note that the ADA spokespersons base their opinion on amalgam safety based totally on mercury levels in the blood, urine or hair. Recent science has shown that these are not measures of total exposure or body burden but likely represent a combination of exposure and the excretion ability of the individual.

iaomtRichard D. Fischer, D.D.S., FAGD, MIAOMT; IAOMT liaison to the IAOMT Scientific advisory board.                       

Vasken Aposhian, PhD, Professor Emeritus of Pharmacology and Professor Emeritus of Cellular and Molecular Biology, University of Arizona, College of Medicine.    

Maths Berlin, MD, PhD, (Advisor to the IAOMT Scientific Advisory Board) Professor Emeritus of Environmental Medicine, Medical Faculty  University of Lund, Sweden; Chairman of two World  Health  Organization conferences on mercury exposure in 1991.

Thomas Burbacher, PhD , Associate Professor of Environmental and Occupational Health Sciences; Research Affiliate, Center on Human Development and Disability; Director, Infant Primate Research Laboratory , University of Washington Center for Human Development and Disability.

Louis W. Chang, PhD, Emeritus Professor of Pathology, University of Arkansas School of Medical Sciences; Founding Director of the Taiwan Division of Environmental Health & Occupational Medicine. 

Boyd Haley, PhD, MIAOMT, (Chairman SAB IAOMT), Professor and former Chairman of the Department of Chemistry, University of Kentucky.Herb Needleman, MD, Professor of Child Psychiatry and Pediatrics, University of Pittsburgh School of Medicine.

The International Academy of Oral Medicine and Toxicology (IAOMT)

iaomt

The International Academy of Oral Medicine and Toxicology is a network of dental, medical and research professionals who seek to raise the standards of scientific biocompatibility in the dental practice with information from the latest interdisciplinary research.

Website: www.iaomt.org

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