Researchers Dr. Mark and David Geier show how the data from the "children's amalgam trial" studies, originally published in the Journal of the American Medical Association, and purported to prove the safety of mercury amalgam, actually show a dose-dependent toxicity in a key metabolic system.

Adverse health effects from exposure to mercury (Hg) exposure from dental amalgam fillings cannot be ruled out in a small and more susceptible part of the exposed population. Individual differences in toxicokinetics may explain susceptibility to mercury. F2 mice showed a large inter-individual variation in Hg accumulation, showing that multiple genetic factors influence the Hg toxicokinetics in the mouse.

Environmental factors can play an important role in the development of autoimmune thyroiditis (AT) and other autoimmune diseases. This article reviews the role of heavy metals and infectious agents in AT.  Memory T lymphocytes can be used as biomarkers of susceptibility to mercury and other inflammation triggers in individual patients. If metal allergy is found, the patient should avoid all exposure to the allergenic substance. Mercury-allergic patients may benefit from replacement of dental amalgam.

The current scientific debate regarding the safety of amalgam dental restorations being conducted in the US is presented. The material is based on a meeting held on December 14 and 15, 2010 by the Dental Products Panel of the Medical Devices Advisory Committee of the Food and Drug Administration. The scientific and historic context of the debate is provided, followed by scientific arguments, public testimony and panel deliberations.

The FDA was charged with evaluating and classifying medical devices in 1976. Amalgam manufacturers have been able to successfully shirk the burden of proving safety, which should rightfully be assigned to them. If the FDA assigns the burden to prove harm to U.S. consumer groups, the FDA condemns itself to perpetual study and inaction. This will result in an ineffective agency and an unprotected public, devastated by preventable degenerative disease.

Dr Michael Margolis presents evidence to the FDA's dental products panel in 2010 that mercury from amalgam fillings is absorbed into the gum and jaw bone

In December 2010 the FDA convened a dental products panel hearing on the safety of dental amalgam. Since that time, Dr. Raymond F. Gist, president of the American Dental Association (ADA) has continually misrepresented the results of these hearings to the public and its membership. Luckily the current availability of the hearing transcripts has allowed the IAOMT the opportunity to correct any misconceptions that may arise from Dr. Gist's statements.

At the end of the FDA dental products panel hearing to evaluate the safety of amalgam, FDA’s scientific panel, including neurologists, toxicologists, epidemiologists, and environmental health specialists concluded that, contrary to the claims of FDA’s in-house dentist Susan Runner, "amalgam is not safe for everybody." and to stop its use in susceptible, at risk populations.

Like many other victims of mercury toxicity, I suffered from numerous autoimmune and mystery illnesses for years before being diagnosed with mercury poisoning. In 2010, my physician recommended I have my six silver fillings, removed immediately. Over the last year, my health has improved far beyond my wildest expectations.

Mike Fleming DDS, served on the FDA dental products panel in 2006 and 2010. In this video he comments on various aspects of the FDA's stance on dental mercury amalgam allergy, including the ADA's statment at the 2006 hearing that 6% of the population (over 7 million people) are allergic to mercury.

Bob Reeves, attorney for The International Academy of Oral Medicine and Toxicology, outlines how the FDA limited consumer voices at the December 2010 hearing on the safety of dental amalgam.

A consumer activist, who attended the 2010 FDA hearings on amalgam safety, videotaped the event and has uploaded many important presentations from the hearings to the youtube channel, mercurymatters. Available videos include consumer safety organizations, scientists, mercury free dentists, injured consumers and dental staff.

The International Academy of Oral Medicine and Toxicology presents the backstory and lead up to the 2010 FDA hearing on amalgam safety.

Recently published in the Journal for Alzheimer's Disease was a study that performed a meta-analysis of 106 case-control or comparative cohort studies to associate mercury as a causative factor in Alzheimer's disease. Noting that the main source of mercury in the human body is dental amalgam (1 - 27 ug a day)