In the present study we describe a strong, positive correlation between mercury exposure from dental amalgam fillings and urinary mercury excretion over a 7-year longitudinal course of amalgam treatment in children. These findings are relevant within the context of children’s health risk assessment and suggest directions for future research to determine whether differential sensitivities to mercury between boys and girls do exist.

The present studies demonstrate significant adverse effects on neurobehavioral functions associated with chronic Hg exposure and the CPOX4 genetic variant among children, with effects manifested predominantly among boys. These findings are the first to describe a genetic polymorphism that modifies the effects of Hg exposure on neurobehavioral functions in children, and suggest directions for future research to define mechanisms underlying differential sensitivity to mercury between boys and girls.

We examined the effect of mercury (Hg) associated with dental amalgam fillings on biomarkers of renal and oxidative stress in children between the ages of 5–15.5 years. Our data provide evidence that low exposure to Hg from dental amalgam fillings exerts an effect on kidney tubular functions in children. Oxidative stress may have played a role in this mechanism. The results of this study would also suggest that urinary NAG is the most sensitive of all the investigated renal biomarkers.

To the Honorable Prosecutor Ocampo. We are requesting you authorize an investigation by the International Criminal Court (ICC) into a crime against humanity under Article 7 of the Rome Statute directed at those responsible for the design, funding, execution, analysis, and publication of an unethical scientific experiment conducted on hundreds of children.  The experiment exposed the children to significant amounts of mercury, a deadly poison, in order to justify the use of dental amalgam fillings.

This study estimated Hg body burden from dental amalgam fillings in 182 children. The detrimental neurobehavioral and/or nephrotoxic effects of such an increased Hg on children should be a cause of concern, and further investigation is warranted. Our results are alarming and indicate an urgent need for biomonitoring and assessment of exposure. Changes in dental practices involving amalgam, especially for children, are highly recommended in order to avoid unnecessary exposure to Hg. 

Exposure to toxic mercury (Hg) is a growing health hazard throughout the world today. Recent studies show that mercury exposure may occur in the environment, and increasingly in occupational and domestic settings. Children are particularly vulnerable to Hg intoxication, which may lead to impairment of the developing central nervous system, as well as pulmonary and nephrotic damage. Several sources of toxic Hg exposure in children have been reported in biomedical literature such as that from dental mercury amalgam fillings.